网上日赚300一800副业

教师简介：

一、基本情况

姓     名：陈吉龙

性     别：男

政治面貌：中国致公网上日赚300一800副业网上日赚300一800副业员

职    称：二级教授

职    务：院长

研究方向：兽医微生物学、兽医免疫学、动物传染病学

联系电话：0591-83789159

电子邮箱：chenjilong@fafu.edu.cn

二、受教育经历

1982-1986年网上日赚300一800副业(原福建农网上日赚300一800副业)　学士

1986-1989年中国农业大学(原北京农业大学)　硕士

1989-1992年北京大学　博士

三、研究工作经历

1992.07-1994.12：中国科网上日赚300一800副业遗传与发育生物学研究所（原中科院发育生物学研究所）工作，任助理研究员，副研究员(中国科网上日赚300一800副业破格提拔)；

1995.01-1998.06：美国爱荷华大学（University of Iowa）生物化学系博士后；

1998.07-2000.11：中国科网上日赚300一800副业遗传与发育生物学研究所，任副研究员、研究员。研究组负责人，青年科学家创新小组负责人；

2000.11-2008.12：美国University of Iowa高级访问学者。出国期间因研究所合并重组，辞去中科院遗传与发育生物学研究所研究员职位并获得批准；

2008.12-2017.04：2008年中国科网上日赚300一800副业“百人计划”引进回国，任中国科网上日赚300一800副业微生物研究所研究员（后晋升为二级研究员），研究组长，博士生导师，国家"973"计划项目首席科学家，中国科网上日赚300一800副业微生物研究所学术委员会委员和学位委员会委员；

2015-2017年：兼任中国科网上日赚300一800副业大学岗位教授，中国科网上日赚300一800副业特聘研究员；

2013.01-至今：网上日赚300一800副业网上日赚300一800副业院长（2017年起全职），二级教授，博士生导师。享受国务院政府特殊津贴专家，福建省“百人计划”入选者，福建省高层次人才（A类），福建省“闽江学者”，福建省兽医学重点学科带头人。

四、科研项目

（1）非细胞因子依赖性的宿主早期抗病毒免疫应答机制，国家自然科学重点项目（联合基金项目），主持，直接经费：265万元，2024.01-2027.12；

（2）动物流感病毒与宿主RNA 互作机制研究，国家重点研发计划课题，主持，总经费：915万元，2021.05-2025.12；

（3）新鉴定的lncRNAs在流感病毒与宿主互作过程中的作用及其机制，国家自然科学基金重点项目，主持，直接经费：285万元，2021.01-2025.12；

（4）STATs蛋白在宿主抗流感病毒天然免疫中的功能研究，国家自然科学基金联合基金项目（联合基金），主持，直接经费：232万元，2019.01-2023.12；

五、承担课程

本科生课程：动物医学专业导论、动物病毒学、预防兽医学实验（一）、形势与政策

研究生课程：高级动物病毒学、兽医生物技术进展、预防兽医学专题、兽医公共卫生学、科技论文写作

六、科研成果

陈吉龙教授长期从事兽医微生物与兽医免疫学、兽医传染病领域科研和教学工作，任国家“973”计划项目首席科学家（2015-2019），先后主持国家自然科学基金重点项目、国家重点研发计划课题、国家“973”计划项目、国家“863”计划课题、国家科技支撑课题等20多个国家级项目；在国内外重要学术刊物上发表论文120多篇，包括以第一作者或通讯作者在国际核心学术刊物Cell Host & Microbe、Lancet、The Lancet Infectious Diseases、PNAS、Nucleic Acids Research、mBio、Blood、PLoS Pathogens、Cancer Research、Cell Reports、Oncogene、Journal of Virology等杂志上发表90多篇SCI论文；获授权发明专利12项；获得福建省自然科学奖二等奖1项（排名第一）、中国侨联中国侨界贡献奖二等奖1项（个人奖）、大北农科技奖创新奖二等奖1项（排名第一）、福建省教学成果特等奖1项（排名第三）、福建省五一先锋号等多项奖励；多次应邀在国际会议上做学术报告或主持会议，得到国际同行的高度认可。

七、代表性论文与著作

1. Biao Chen#, Guijie Guo#, Guoqing Wang#, Qianwen Zhu, Lulu Wan, Wenhao Shi, Song Wang, Yuhai Chen, Xiaojuan Chi, Faxin Wen, Mohamed Maarouf, Shile Huang, Zhou Yang and Ji-Long Chen*. ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus. PLOS Pathogens. 2024, 20(1):e1011958. (*为通讯作者，下同)

2. ShashaLiu#, Siya Liu#, Ziding Yu#, Wenzhuo Zhou, Meichun Zheng, RongrongGu, JinxuanHong, Zhou Yang, Xiaojuan Chi, GuijieGuo, Xinxin Li, Na Chen, Shile Huang, Song Wang and Ji-Long Chen*. STAT3 regulates antiviral immunity by suppressingexcessive interferon signaling. Cell Reports. 2023;42(7):112806.

3. KulRaj Rai#, Yuan Liao#, MengjuanCai#, HaoriQiu, Faxin Wen, Min Peng, Song Wang,Shasha Liu, GuijieGuo, Xiaojuan Chi, Mohamed Maarouf, Yuhai Chen, Shile Huang and Ji-Long Chen*. MIR155HG plays abivalent role in regulating innate antiviral immunity by encoding longnoncoding RNA-155 and microRNA-155-5p. mBio. 2022, e0251022 .

4. Yun Ma#, GuijieGuo#, Tingting Li, Faxin Wen, JianlingYang,Biao Chen, Xuefei Wang and Ji Long Chen*. A novel imatinib-upregulated long noncoding RNA plays acritical role in inhibition of tumor growth induced by Abl oncogenes. Molecular Cancer. 2022, 21(1):5.

5. Yingying Li, Shasha Liu, Yuhai Chen, Biao Chen, Meng Xiao, Bincai Yang, Kul Raj Rai,MohamedMaarouf, GuijieGuo* and Ji-Long Chen*. Syk facilitates influenza A virus replication by restraining innate immunityat the late stage of viral infection. Journal of Virology. 2022; doi:10.1128/jvi.00200-22 [51].

6. Shasha Liu Yuan Liao, Biao Chen, Yuhai Chen, Ziding Yu, Haitao Wei, Lianfeng Zhang, Shile Huang, Paul B. Rothman, George Fu Gao and Ji-Long Chen*. Critical role of Syk-dependent STAT1 activation ininnate antiviral immunity. Cell Reports, 2021,34(3):108627. doi:10.1016/j.celrep.2020.108627.

7. Meng Xiao, Yuhai Chen, Song Wang, ShashaLiu,Kul Raj Rai, Biao Chen, Fang Li, Yingying Li, Mohamed Maarouf and Ji-Long Chen*. Long Noncoding RNAIFITM4P regulates host antiviral responses by acting as a ceRNA. Journal of Virology, 2021,doi: 10.1128/JVI.00277-21.

8. Qingsen Wang, Wenliang Pan, Song Wang, Chen Pan, Hongya Ning, Shile Huang, Shih-HsinChiu* and Ji-Long Chen*. Protein tyrosine phosphatase SHP2 suppresses host innate immunity againstinfluenza A virus through regulating EGFR-mediated signaling. Journal of Virology, 2021,95(6):e02001-20.

9. Biao Chen, Yuhai Chen, Kul Raj Rai, XuefeiWang,Shasha Liu, Yingying Li, Meng Xiao, Yun Ma, Guoqing Wang, GuijieGuo, Shile Huang and Ji-Long Chen*. Deficiencyof eIF4B Increases Mouse Mortality and Impairs Antiviral Immunity. Frontiers in Immunology. 2021;12:723885. doi: 10.3389/fimmu.2021.723885.

10. Kul Raj Rai, Biao Chen, Zhonghui Zhao, YuhaiChen, Jiayue Hu, Shasha Liu, Mohamed Maarouf, Yingying Li, Meng Xiao, Yuan Liao and Ji-Long Chen*. Robustexpression of p27Kip1 induced by viral infection is critical for antiviralinnate immunity. Cellular Microbiology. 2020, e13242.

11. Jiayue Hu, George Fu Gao and Ji-Long Chen*. Strengthening the role of ethnic minority women in science and medicineinChina. Lancet, 2019;393(10171):527-528.

12. Ye Chen, Jin Tian and Ji-Long Chen*. Challenges to eliminaterabies virus infection inChina by 2020. The Lancet Infectious Diseases, 2017,17(2): 135-136.

13. Fang Li, Yuhai Chen, Zhaoyuan Zhang, Jing Ouyang, Yi Wang, Ruoxiang Yan, Shile Huang, George Fu Gao, GuijieGuo and Ji-Long Chen*. Robust expression of vault RNAs induced by influenza A virus plays a critical role in suppression of PKR-mediated innate immunity. Nucleic Acids Research, 2015; 43(21):10321-37.

14. Jing Ouyang, Xiaomei Zhu, Yuhai Chen, Haitao Wei, Qinghuang Chen, Xiaojuan Chi, Baomin Qi, Lianfeng Zhang, Yi Zhao, George Fu Gao, Guoshun Wang and Ji-Long Chen*. NRAV, a Long Noncoding RNA, Modulates Antiviral Responses through Suppression of Interferon-Stimulated Gene Transcription. Cell Host & Microbe, 2014; 16(5):616-626.

15. Haitao Wei, Song Wang, Qinghuang Chen, Yuhai Chen, Xiaojuan Chi, Lianfeng Zhang, Shile Huang, George Fu Gao and Ji-Long Chen*. Suppression of Interferon Lambda Signaling by SOCS-1 Results in Their Excessive Production during Influenza Virus Infection. PLoS Pathogens, 2014; 10(1):e1003845.

16. Song Wang, Xiaojuan Chi, Haitao Wei, Yuhai Chen, Zhilong Chen, Shile Huang and Ji-Long Chen*. Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to the viral replication by suppressing IFITM3 protein expression. Journal of Virology, 2014; 88(15):8375-8385.

17. Jianling Yang, Jun Wang, Ke Chen, GuijieGuo, Ruijiao Xi, Paul B. Rothman, Douglas Whitten, Lianfeng Zhang, Shile Huang and Ji-Long Chen*. eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation by Abl Oncogenes. Cancer Research, 2013; 73(15): 4898-4908.

18. Song Wang, Hua Li, Yuhai Chen, Haitao Wei, George F.Gao. , Hongqiang Liu, Shile Huang and Ji-Long Chen*. Transport of influenza A virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42. The Journal of Biological Chemistry, 2012, 287 (13): 9804-9816.

19. GuijieGuo, Qingzheng Kang, Xiaomei Zhu, Qinghuang Chen, Xuefei Wang, Yuhai Chen, Jing Ouyang, Lianfeng Zhang, Huo Tan, RunshengChen,Shile Huang and Ji-Long Chen*. A long noncoding RNA critically regulates Bcr-Abl-mediatedcellular transformation by acting as a competitive endogenous RNA. Oncogene, 2015;34(14):1768-1779.

20. GuijieGuo, XiaoxueQiu, Song Wang, Yuhai Chen, Paul B. Rothman, Zixu Wang, YaoxingChen, Guoshun Wang and Ji-Long Chen*. The oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B cell transformation and survival of Pim-deficient cells. Oncogene, 2010,29:3845–3853.

21. Xuefei Wang, Shile Huang and Ji-Long Chen*. Understanding of leukemic stem cells and their clinical implications. Molecular Cancer, 2017; 16(1):2.

22. Xuefei Wang, Jianling Yang, GuijieGuo, Riyue Feng, Ke Chen, Yuan Liao, Lianfeng Zhang, Liping Sun, Shile Huang and Ji-Long Chen*. Novel lncRNA-IUR suppresses Bcr-Abl-induced tumorigenesis through regulation of STAT5-CD71 pathway. Molecular Cancer, 2019,18(1):84-95.

23. Song Wang, Lanlan Zhang, Rong Zhang, Xiaojuan Chi, Zhou Yang, YanhuiXie, Sicheng Shu, Yuan Liao and Ji-Long Chen*. Identification of two residues within the NS1 of H7N9 influenza A virus that critically affect the protein stability and function. Veterinary Research, 2018,49(1):98.

24. Yuhai Chen, Jing Ouyang, Ruoxiang Yan, Mohamed Hassan Maarouf, Xuefei Wang, Biao Chen, Shasha Liu, Jiayue Hu, GuijieGuo, Jing Zhang, Sheng-Ming Dai, Huji Xu and Ji-Long Chen*. Silencing SOCS3 Markedly Deteriorates Spondyloarthritis in Mice Induced by Minicircle DNA Expressing IL23. Frontiers in Immunology. 2018,9:2641. doi: 10.3389/fimmu.2018.02641.

25. Riyue Feng, Xuefei Wang, Ke Chen, GuijieGuo, Yuan Liao, Liping Sun, Shile Huang and Ji-Long Chen*. Interaction of Abl Tyrosine Kinases with SOCS3 Impairs Its Suppressor Function in Tumorigenesis. Neoplasia, 2018,20(11):1095-1105.

26. Xiaoyong Chen, Shasha Liu, Mohamed Maarouf, Shile Huang and Ji-Long Chen*. Host immune response to influenza A virus infection. Frontiers in Immunology. 2018; 9:320.

27. Shi-long Chen, Guifeng Luo, Zhou Yang, Shuncheng Lin, Shaoying Chen, Song Wang, MohsanUlahGoraya, Xiaojuan Chi, Xiancheng Zeng and Ji-Long Chen*. Avian Tembusu virus infection effectively triggers host innate immune response through MDA5 and TLR3-dependent signaling pathways. Veterinary Research, 2016; 47(1):74.

28. Jingyun Wei, Yanmei Ma, Long Wang, Xiaojuan Chi, Ruoxiang Yan, Song Wang, Xinxin Li, Xiaoyong Chen, Wenhan Shao and Ji-Long Chen*. Alpha/beta interferon receptor deficiency in mice significantly enhances susceptibility of the animals to pseudorabies virus infection. Veterinary Microbiology. 2017; 203:234-244.

29. BinxiangCai, Qingling Bai, Xiaojuan Chi, MohsanUllahGoraya, Long Wang, Song Wang, Biao Chen and Ji-Long Chen*. Infection with classical swine fever virus induces expression of type III interferons and activates innate immune signaling. Frontiers in Microbiology, 2017;8:2558.

30. Song Wang, Xiaoqin Luo, Ruoxiang Yan, Quanxin Wang, Qiuyue Qi, Xiaojuan Chi, Lanlan Zhang, ZidingYu ,BinxiangCai, Ji-Long Chen* and Hongwei Liu*. 3-anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection. Protein & cell, 2016; 7(11):839-843.

31. Jing Ouyang, Jiayue Hu and Ji-long Chen*. lncRNAs regulate the innate immune response to viralinfection. Wiley Interdisciplinary Reviews-RNA, 2016, 7(1):129-143.

32. Zhilong Chen, Guifeng Luo, Quanxi Wang*, Song Wang*, Xiaojuan Chi, Yifan Huang, Haitao Wei, Baocheng Wu, Shile Huang and Ji-Long Chen*. Muscovy duck reovirus infection rapidly activates host innate immune signaling and induces an effective antiviral immune response involving critical interferons. Veterinary Microbiology, 2015; 175(2-4):232-243.

33. MohsanUllahGoraya, Song Wang, Muhammad Munir and Ji-Long Chen*. Induction of innate immunity and its perturbation by influenza viruses. Protein & Cell, 2015;6(10):712-721.

34. GuijieGuo, Qingzheng Kang, Qinghuang Chen, Zhilong Chen, Jun Wang, Li Tan and Ji-Long Chen*. High expression of long noncoding RNA H19 is required for efficient tumorigenesis induced byBcr-Abloncogene. FEBS Letters, 2014; 588(9):1780-1786.

35. Ji-Long Chen, Andre Limnander and Paul B. Rothman. Pim-1 and Pim-2 kinases are required for Pre-B cell transformation by v-Abl oncogene. Blood, 2008,111(3):1677-1685.

36. Ji-Long Chen, Raymond V.Fucini, Lynne Lacomis, HediyeErdjument-Bromage, Paul Tempst and Mark Stamnes*. Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles. Journal of Cell Biology, 2005, 169(3):383-389.

37. Ji-Long Chen, Kathryn L.Huisinga, Michaela M. Viering, Sharon A. Ou, C.-ting Wu and Pamela K. Geyer*. Enhancer action in trans is permitted throughout the Drosophila genome. Proceedings of The National Academy of Sciences of The United States of America, 2002, 99(6):3723-3728.

38. Ji-Long Chen, JatinderP.Ahluwalia and Mark Stamnes*. Selective effects of calcium chelators on anterogradeand retrograde protein transport in the cell. Journal of Biological Chemistry, 2002,277(38):35682-7.